Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies
نویسندگان
چکیده
منابع مشابه
Untargeted metabolomics.
Along with genes and proteins, metabolites play important roles in sustaining life. Their functions include "primary" functions in metabolism and energy storage, as well as "secondary" functions in cell-to-cell signaling, metal acquisition, and virulence. There remains much to be learned about the in vivo roles of metabolites. Approaches that accelerate measurement of metabolite levels directly...
متن کاملOpium use and mortality in Golestan Cohort Study: prospective cohort study of 50 000 adults in Iran OPEN ACCESS
Objectives To investigate the association between opium use and subsequent risk of death. Design Prospective cohort study. Setting The Golestan Cohort Study in north-eastern Iran collected detailed validated data on opium use and other exposures at baseline. Participants were enrolled between January 2004 and June 2008 and were followed to May 2011, with a follow-up success rate of over 99%. Pa...
متن کاملOpium use and mortality in Golestan Cohort Study: prospective cohort study of 50 000 adults in Iran
OBJECTIVES To investigate the association between opium use and subsequent risk of death. DESIGN Prospective cohort study. SETTING The Golestan Cohort Study in north-eastern Iran collected detailed validated data on opium use and other exposures at baseline. Participants were enrolled between January 2004 and June 2008 and were followed to May 2011, with a follow-up success rate of over 99%...
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Warfarin (Coumadin®) is one of the most widely prescribed anticoagulant drugs used to treat and prevent thrombosis in patients with cardiovascular or other thrombotic disorders (Keeling et al, 2011). Warfarin inhibits vitamin K epoxide reductase and decreases vitamin K hydroquinone to attenuate blood coagulation by inhibiting vitamin K-dependent posttranslational modifications of plasma coagula...
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Bottromycin A2 is a structurally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug-resistant bacteria. The structural novelty of bottromycin stems from its unprecedented macrocyclic amidine and rare β-methylated amino acid residues. The N-terminus of a precursor peptide (BtmD) is converted into bottromy...
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ژورنال
عنوان ژورنال: Frontiers in Nutrition
سال: 2020
ISSN: 2296-861X
DOI: 10.3389/fnut.2020.584585